منابع مشابه
Metabolism Supports Macrophage Activation
Macrophages are found in most tissues of the body, where they have tissue- and context-dependent roles in maintaining homeostasis as well as coordinating adaptive responses to various stresses. Their capacity for specialized functions is controlled by polarizing signals, which activate macrophages by upregulating transcriptional programs that encode distinct effector functions. An important con...
متن کاملMetabolism Fine-tunes Macrophage Activation
C ells continually monitor the availability of nutrients and alter their activities and metabolism accordingly. Immune cells are no exception (O’Neill and Pearce, 2015). Macrophages are important immune cells that perform many roles – they are, for example, involved in development and wound repair – but they need to be activated before they can carry out their functions. For years it was though...
متن کاملThe role of PI3Kγ in metabolism and macrophage activation
The class 1 phosphoinositide 3-kinase (PI3K) is a family of enzymes which add a phosphate group in position 3 to the membrane lipid phosphatidylinositol4,5-bisphosphate to generate the second-messenger phosphatidylinositol-3,4,5-trisphosphate. The class-1 PI3K family is further subdivided into class-1A and class1B. Class-1A PI3Ks comprises PI3Kα; PI3Kβ; and PI3Kδ, which are typically recruited ...
متن کاملC/EBPα regulates macrophage activation and systemic metabolism.
Macrophage infiltration plays an important role in obesity-induced insulin resistance. CCAAT enhancer-binding protein-α (C/EBPα) is a transcription factor that is highly expressed in macrophages. To examine the roles of C/EBPα in regulating macrophage functions and energy homeostasis, macrophage-specific C/EBPα knockout (MαKO) mice were created. Chow-fed MαKO mice exhibited higher body fat mass...
متن کاملAlternative macrophage activation and the regulation of metabolism
Macrophages are white blood cells that have important roles in phagocytosis and immune responses. A series of recent papers reveals that nuclear receptors influence the precise pathway of macrophage phenotype polarization and that these effects protect against insulin resistance and metabolic syndrome, the most important group of diseases facing the industrialized world.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2017
ISSN: 1664-3224
DOI: 10.3389/fimmu.2017.00061